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Limbic encephalitis (LE) associated with glutamic acid decarboxylase antibodies (GAD-Ab) is rare. We describe a 30-year-old male with acute LE and GAD- Ab, with follow-up during 2 years of cognitive status including verbal episodic memory, number of seizures recorded by high-resolution video-EEG, brain MRI, 2-[18F]-fluoro-2-deoxyglucose PET and GAD-Ab titres. Treatment with corticosteroids, IV immunoglobulins, immunosuppressors and antiepileptic drugs resulted in improved memory status, disappearance of seizures and decreased GAD-Ab titres. Review of the other cases of literature and this case in is favour of the existence of autoimmune LE associated with GAD-Ab and supports the link between memory, temporal seizures and possibly GAD-Ab titres. |
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amnesia
amnesia,anterograde
amygdala
CAT scan,emission
CAT scan,emission,abnormal
cerebrospinal fluid,oligoclonal IgG in
electroencephalogram,abnormalities of
encephalitis
encephalitis,autoimmune
gammaglobulin therapy,intravenous
glutamic acid decarboxylase,antibody
immunosuppressive agents
limbic encephalitis
memory,impairment of
MRI,abnormal
prognosis
seizure
seizure,psychomotor-temporal lobe
temporal lobe
temporal lobe,lesion
temporal lobe,lesion,bilateral
treatment of neurologic disorder
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